If God were a zillionaire, this is the blog he would buy.
Pants.Antsy.Pantsy.When one is uncomfortable in one's pants. (Perhaps because they are umbilical corduroys.)
I thought of some more uncomfortable, grosser pants...Underwear.Areolae.Underweareolae.(Boxers made out of nipples.)
Would it be wrong to say those may be very comfortable?